Of note is usually that, because of PEA’s higher lipophilicity, micronized or extremely-micronized formulations are considered to generally be more very easily absorbable, with more favorable pharmacokinetics and larger efficacy. While There's some evidence supporting this concept, there is still no evidence of the superiority of micronized PEA [
2015). These scientific studies, taken jointly, counsel that, Though a immediate activation of GPR55 or PPAR‐α happens, PEA can generate its anti‐inflammatory motion from the gut also by using oblique activation of CB1 and CB2 receptors, possibly as a consequence of the flexibility of this compound to potentiate the motion of endocannabinoids
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